Research

Disclaimer: The following peer-reviewed studies are provided for educational and informational purposes only. This research explores the individual ingredients found in our formula and is not intended to make medical claims about our specific product. These studies do not constitute medical advice, nor should they be interpreted as claims that our product can diagnose, treat, cure, or prevent any disease. Individual results may vary, and you should consult with a healthcare professional before starting any supplement regimen. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

  1. Khaksarian M, others. The efficacy of Crocus sativus (saffron) versus placebo and fluoxetine in treating depression: a systematic review and meta-analysis. Psychology Research and Behavior Management 12:297-305 (2019).
  2. Toth B, others. The efficacy of saffron in the treatment of mild to moderate depression: A meta-analysis. Planta Medica 85:24-31 (2019).
  3. Ghaderi A, others. Effects of saffron (Crocus sativus L.) on mental health parameters and C-reactive protein: A meta-analysis of randomized clinical trials. Complementary Therapies in Medicine 48, 102250; doi.org/10.1016/j.ctim.2019.102250 (7 pages) (2020).
  4. Paula Almodóvar, David Briskey, Amanda Rao, Marín Prodanov, Antonio M. Inarejos-García, "Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract", Evidence-Based Complementary and Alternative Medicine, vol. 2020, Article ID 1575730, doi.org/10.1155/2020/1575730 (8 pages) (2020). 
  5. Kell G, others. affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complementary Therapies in Medicine 33:58-64 (2017).
  6. Cox KH et al. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. Centre for Human Psychopharmacology, Swinburne University. J Psychopharmacol. May 2015. (Vol 29) No 5: 642-651. DOI: 10.1177/0269881114552744
  7. Cox KHM, White DJ, Pipingas A, Poorun K, Scholey A. Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study. Nutrients. 2020 Jun 4;12(6):1678. doi: 10.3390/nu12061678. PMID: 32512782; PMCID: PMC7352411.
  8. Maret W. Zinc biochemistry: From a single zinc enzyme to a key element of life. Advances in Nutrition 4:82-91 (2013). 
  9. Portbury SD, Adlard PA. Zinc signal in brain diseases. International Journal of Molecular Sciences 18, 2506; doi:10.3390/ijms18122506 (13 pages) (2017). 
  10. NIH Office of Dietary Supplements. Zinc Fact Sheet for Health Professionals. ods.od.nih.gov (12 pages) (July 10, 2019, accessed February 24, 2020). 
  11. Petrilli MA, others. The emerging role for zinc in depression and psychosis. Frontiers in Pharmacology 8, 414; doi: 10.3389/fphar.2017.00414 (12 pages) (2017). 
  12. Yosaee S, others. Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2x2 factorial design, double-blind, randomized, placebo-controlled trial. Nutrition 71:110601; doi: 10.1016/j.nut.2019.110601 (2020).